Sertoli-Leydig Cell Tumor of Ovary, Management and Prognosis: A Review of Literature

Sertoli-Leydig cell tumor of ovary is a rare type of sex-cord stromal tumor. Only few case reports are published in the literature. The majority of the cases occur in young women and are benign and unilateral in location. Nearly, 30-40% of the patients present symptoms and signs of virilization. In most of the cases, histopathologically, the degree of differentiation is intermediate or poor. Majority cases are diagnosed at Stage I and extraovarian spread at the time of diagnosis are very uncommon. The degree of tumor grading/differentiation and staging are important prognostic factors. The rarity of the tumor results in inadequate data regarding management protocol. Surgery is the important initial treatment part. Chemotherapy is indicated in the presence of poor prognostic factors, but, controversy exists. There is a need for more number of studies for a standard treatment protocol including chemotherapy.